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It may take one month or more for you to start feeling better. Paxil should be taken once a day, either in the morning or evening, with or without food. Recent studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. You start feeling better and unpleasant side effects may be experienced if you stop taking Paroxetine. Studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. Depression is often associated with other symptoms, such as muscle tension, irritability and disturbedsleep.